Drug interactions
Miconazole + Progesterone intravaginal
Severity: Moderate
Miconazole and Progesterone intravaginal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progesterone vaginal gel relies on bioadhesive absorption across the vaginal mucosa. Another vaginal product such as miconazole may change how the gel is retained and absorbed, so progesterone exposure could become unpredictable. This matters when the progesterone is used for luteal support or endometrial protection.
What this interaction means in plain words
Miconazole and Progesterone intravaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Concurrent vaginal products may alter retention and mucosal absorption of the progesterone gel; this is a theoretical local effect rather than a proven one.
What to do
Avoid using miconazole vaginal products during progesterone gel therapy where possible, or consider oral antifungal therapy. If both are needed, apply them at least several hours apart and watch for signs of reduced progesterone effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miconazole
Frequently asked questions
Can I take Miconazole with Progesterone intravaginal?
MediHelp rates the interaction as moderate. Miconazole and Progesterone intravaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Progesterone vaginal gel relies on bioadhesive absorption across the vaginal mucosa. Another vaginal product such as miconazole may change how the gel is retained and absorbed, so progesterone exposure could become unpredictable. This matters when the progesterone is used for luteal support or endometrial protection.
How serious is the interaction between Miconazole and Progesterone intravaginal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using miconazole vaginal products during progesterone gel therapy where possible, or consider oral antifungal therapy. If both are needed, apply them at least several hours apart and watch for signs of reduced progesterone effect.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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