Drug interactions
Lovastatin + Miconazole
Severity: Major
Lovastatin and Miconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic miconazole can raise lovastatin exposure and increase the risk of myopathy and rhabdomyolysis. With vaginal use absorption is limited, but case reports exist with miconazole preparations and statins.
What this interaction means in plain words
Lovastatin and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Lovastatin belongs to Cardiovascular; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4 metabolism of lovastatin.
What to do
Avoid with oral or buccal miconazole; hold lovastatin during treatment. With vaginal use, monitor for muscle pain or weakness, or temporarily switch to pravastatin or rosuvastatin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Miconazole
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Frequently asked questions
Can I take Lovastatin with Miconazole?
MediHelp rates the interaction as major. Lovastatin and Miconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic miconazole can raise lovastatin exposure and increase the risk of myopathy and rhabdomyolysis. With vaginal use absorption is limited, but case reports exist with miconazole preparations and statins.
How serious is the interaction between Lovastatin and Miconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid with oral or buccal miconazole; hold lovastatin during treatment. With vaginal use, monitor for muscle pain or weakness, or temporarily switch to pravastatin or rosuvastatin.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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