Drug interactions
Miconazole + Triazolam
Severity: Moderate
Miconazole and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole inhibits CYP3A4, and triazolam is a sensitive CYP3A4 substrate, so exposure can rise with enhanced sedation and psychomotor impairment. Vaginal use gives limited systemic exposure, but oral gel or higher absorption raises concern.
What this interaction means in plain words
Miconazole and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Miconazole inhibits CYP3A4-mediated oxidative metabolism of triazolam, reducing its clearance.
What to do
Monitor for excessive sedation and consider a lower triazolam dose, particularly with oral gel or prolonged miconazole use. Consider a benzodiazepine not metabolised by CYP3A4, such as lorazepam or temazepam, if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Miconazole and Triazolam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Miconazole
Frequently asked questions
Can I take Miconazole with Triazolam?
MediHelp rates the interaction as moderate. Miconazole and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miconazole inhibits CYP3A4, and triazolam is a sensitive CYP3A4 substrate, so exposure can rise with enhanced sedation and psychomotor impairment. Vaginal use gives limited systemic exposure, but oral gel or higher absorption raises concern.
How serious is the interaction between Miconazole and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider a lower triazolam dose, particularly with oral gel or prolonged miconazole use. Consider a benzodiazepine not metabolised by CYP3A4, such as lorazepam or temazepam, if needed.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
