Drug interactions
Miconazole vaginal + Nateglinide
Severity: Minor
Miconazole vaginal and Nateglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole is a CYP2C9 inhibitor and systemic absorption from vaginal products is small but can be measurable. This could theoretically raise nateglinide levels and the risk of hypoglycemia, although significant effects are uncommon with short courses.
What this interaction means in plain words
Miconazole vaginal and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP2C9-mediated nateglinide metabolism by absorbed miconazole.
What to do
No routine adjustment is needed; advise patients to watch for hypoglycemia symptoms and check glucose if using prolonged or repeated courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nateglinide
- Albiglutide + Nateglinide Moderate
- Alogliptin-metformin + Nateglinide Moderate
- Alogliptin-pioglitazone + Nateglinide Moderate
- Alogliptin + Nateglinide Moderate
- Alpelisib + Nateglinide Moderate
- Amiodarone + Nateglinide Moderate
Frequently asked questions
Can I take Miconazole vaginal with Nateglinide?
MediHelp rates the interaction as minor. Miconazole vaginal and Nateglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miconazole is a CYP2C9 inhibitor and systemic absorption from vaginal products is small but can be measurable. This could theoretically raise nateglinide levels and the risk of hypoglycemia, although significant effects are uncommon with short courses.
How serious is the interaction between Miconazole vaginal and Nateglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; advise patients to watch for hypoglycemia symptoms and check glucose if using prolonged or repeated courses.
What other medicines interact with Nateglinide?
MediHelp also lists interactions of Nateglinide with, for example, Albiglutide, Alogliptin-metformin, Alogliptin-pioglitazone. The full list is on the Nateglinide page.
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