Drug interactions
Miconazole vaginal + Nifedipine
Severity: Minor
Miconazole vaginal and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole is absorbed to a small degree, but miconazole is a CYP3A4 inhibitor and may slightly raise nifedipine levels. Clinically significant effects are uncommon with short topical courses.
What this interaction means in plain words
Miconazole vaginal and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 metabolism of nifedipine by systemically absorbed miconazole.
What to do
No routine change is needed; watch for hypotension, flushing or ankle edema during prolonged or repeated courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Frequently asked questions
Can I take Miconazole vaginal with Nifedipine?
MediHelp rates the interaction as minor. Miconazole vaginal and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole is absorbed to a small degree, but miconazole is a CYP3A4 inhibitor and may slightly raise nifedipine levels. Clinically significant effects are uncommon with short topical courses.
How serious is the interaction between Miconazole vaginal and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; watch for hypotension, flushing or ankle edema during prolonged or repeated courses.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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