Drug interactions
Miconazole vaginal + Quinine
Severity: Minor
Miconazole vaginal and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole inhibits CYP3A4, and quinine is cleared mainly by CYP3A4. Vaginal use gives low systemic exposure, so a meaningful rise in quinine levels is unlikely in most patients.
What this interaction means in plain words
Miconazole vaginal and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Miconazole inhibits CYP3A4, which could reduce quinine metabolism, though systemic absorption from vaginal use is limited.
What to do
No action is usually needed. Monitor for cinchonism or QT-related symptoms if quinine is used with prolonged or repeated vaginal miconazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Miconazole vaginal with Quinine?
MediHelp rates the interaction as minor. Miconazole vaginal and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miconazole inhibits CYP3A4, and quinine is cleared mainly by CYP3A4. Vaginal use gives low systemic exposure, so a meaningful rise in quinine levels is unlikely in most patients.
How serious is the interaction between Miconazole vaginal and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed. Monitor for cinchonism or QT-related symptoms if quinine is used with prolonged or repeated vaginal miconazole.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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