Drug interactions
Miconazole vaginal + Repaglinide
Severity: Minor
Miconazole vaginal and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole has limited systemic absorption but can inhibit CYP enzymes, and interactions have been reported with oral anticoagulants. A small rise in repaglinide exposure is possible, with a low chance of hypoglycemia.
What this interaction means in plain words
Miconazole vaginal and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Systemically absorbed miconazole may inhibit CYP3A4 and CYP2C8, reducing repaglinide metabolism.
What to do
No routine adjustment is needed for a short vaginal course; monitor blood glucose and watch for hypoglycemia, especially with repeated or prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Miconazole vaginal with Repaglinide?
MediHelp rates the interaction as minor. Miconazole vaginal and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole has limited systemic absorption but can inhibit CYP enzymes, and interactions have been reported with oral anticoagulants. A small rise in repaglinide exposure is possible, with a low chance of hypoglycemia.
How serious is the interaction between Miconazole vaginal and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed for a short vaginal course; monitor blood glucose and watch for hypoglycemia, especially with repeated or prolonged use.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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