Drug interactions
Midazolam intranasal + Nilotinib
Severity: Moderate
Midazolam intranasal and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits CYP3A4 and may increase midazolam exposure. This can lead to deeper or longer sedation and respiratory depression.
What this interaction means in plain words
Midazolam intranasal and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated midazolam metabolism by nilotinib.
What to do
Monitor sedation level and respiratory status for longer than usual after dosing. Avoid repeat dosing too soon and consider a lower dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Midazolam intranasal with Nilotinib?
MediHelp rates the interaction as moderate. Midazolam intranasal and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib inhibits CYP3A4 and may increase midazolam exposure. This can lead to deeper or longer sedation and respiratory depression.
How serious is the interaction between Midazolam intranasal and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status for longer than usual after dosing. Avoid repeat dosing too soon and consider a lower dose.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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