Drug interactions
Midazolam intranasal + Oxcarbazepine
Severity: Moderate
Midazolam intranasal and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine can cause sedation, and with midazolam the CNS and respiratory depressant effects may be additive. This raises the risk of hypoventilation and prolonged sedation.
What this interaction means in plain words
Midazolam intranasal and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; oxcarbazepine may also modestly induce CYP3A4 and lower midazolam exposure.
What to do
Monitor respiratory rate, oxygen saturation and sedation level after the midazolam dose. Use the lowest effective dose and have resuscitation equipment available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Midazolam intranasal with Oxcarbazepine?
MediHelp rates the interaction as moderate. Midazolam intranasal and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine can cause sedation, and with midazolam the CNS and respiratory depressant effects may be additive. This raises the risk of hypoventilation and prolonged sedation.
How serious is the interaction between Midazolam intranasal and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate, oxygen saturation and sedation level after the midazolam dose. Use the lowest effective dose and have resuscitation equipment available.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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