Drug interactions
Midazolam intranasal + Pimavanserin
Severity: Moderate
Midazolam intranasal and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam causes dose-dependent sedation and respiratory depression, which may be increased by other CNS depressants such as pimavanserin. Excess sedation, hypoventilation or apnea could result.
What this interaction means in plain words
Midazolam intranasal and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and respiratory depressant effects.
What to do
Monitor respiratory rate, oxygen saturation and level of consciousness after midazolam dosing, and ensure supervision and resuscitation capability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Midazolam intranasal with Pimavanserin?
MediHelp rates the interaction as moderate. Midazolam intranasal and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam causes dose-dependent sedation and respiratory depression, which may be increased by other CNS depressants such as pimavanserin. Excess sedation, hypoventilation or apnea could result.
How serious is the interaction between Midazolam intranasal and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate, oxygen saturation and level of consciousness after midazolam dosing, and ensure supervision and resuscitation capability.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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