Drug interactions
Midazolam intranasal + Quinine
Severity: Moderate
Midazolam intranasal and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine can inhibit CYP3A4 weakly and may increase midazolam exposure. This can lengthen or deepen sedation and add to respiratory depression risk.
What this interaction means in plain words
Midazolam intranasal and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Quinine inhibits CYP3A4, reducing midazolam clearance.
What to do
Monitor sedation level and respiratory status after the midazolam dose. Avoid repeat dosing until the effect has fully worn off.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Midazolam intranasal with Quinine?
MediHelp rates the interaction as moderate. Midazolam intranasal and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine can inhibit CYP3A4 weakly and may increase midazolam exposure. This can lengthen or deepen sedation and add to respiratory depression risk.
How serious is the interaction between Midazolam intranasal and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status after the midazolam dose. Avoid repeat dosing until the effect has fully worn off.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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