Drug interactions
Minocycline + Mipomersen
Severity: Moderate
Minocycline and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can cause hepatotoxicity with raised transaminases and hepatic steatosis. Minocycline has rarely caused liver injury, including autoimmune-type hepatitis, so the combination could add to hepatic risk and complicate attribution.
What this interaction means in plain words
Minocycline and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential through pharmacodynamic overlap; no pharmacokinetic interaction is established.
What to do
Check ALT, AST and bilirubin before and regularly during combined use. Stop the suspected agent if significant liver enzyme elevation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Minocycline
- Acitretin + Minocycline Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Cholera vaccine + Minocycline Major
- Methoxyflurane + Minocycline Major
- Minocycline + Palovarotene Major
- Minocycline + Pexidartinib Major
Frequently asked questions
Can I take Minocycline with Mipomersen?
MediHelp rates the interaction as moderate. Minocycline and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen can cause hepatotoxicity with raised transaminases and hepatic steatosis. Minocycline has rarely caused liver injury, including autoimmune-type hepatitis, so the combination could add to hepatic risk and complicate attribution.
How serious is the interaction between Minocycline and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ALT, AST and bilirubin before and regularly during combined use. Stop the suspected agent if significant liver enzyme elevation develops.
What other medicines interact with Minocycline?
MediHelp also lists interactions of Minocycline with, for example, Acitretin, Isotretinoin, Cholera vaccine. The full list is on the Minocycline page.
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