Drug interactions
Mipomersen + Naproxen
Severity: Moderate
Mipomersen and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises liver transaminases and causes hepatic fat accumulation. Naproxen can rarely cause liver injury, so concurrent use may complicate liver monitoring.
What this interaction means in plain words
Mipomersen and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential for hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Monitor liver enzymes and bilirubin at the intervals required for mipomersen. Stop the offending agent if transaminases rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Mipomersen with Naproxen?
MediHelp rates the interaction as moderate. Mipomersen and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen commonly raises liver transaminases and causes hepatic fat accumulation. Naproxen can rarely cause liver injury, so concurrent use may complicate liver monitoring.
How serious is the interaction between Mipomersen and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin at the intervals required for mipomersen. Stop the offending agent if transaminases rise significantly.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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