Drug interactions
Mipomersen + Niacin
Severity: Moderate
Mipomersen and Niacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both mipomersen and niacin can raise liver transaminases and cause liver injury. Used together, hepatotoxicity may be more likely or more difficult to attribute to one agent.
What this interaction means in plain words
Mipomersen and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity; mipomersen causes hepatic fat accumulation and transaminase elevation, and niacin is independently hepatotoxic.
What to do
Monitor ALT, AST and bilirubin at baseline and regularly during combined therapy. Stop or reduce therapy if transaminases rise significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Niacin
- Alogliptin-metformin + Niacin Moderate
- Atorvastatin + Niacin Moderate
- Canagliflozin-metformin + Niacin Moderate
- Cholestyramine + Niacin Moderate
- Colestipol + Niacin Moderate
- Dapagliflozin-metformin + Niacin Moderate
Frequently asked questions
Can I take Mipomersen with Niacin?
MediHelp rates the interaction as moderate. Mipomersen and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both mipomersen and niacin can raise liver transaminases and cause liver injury. Used together, hepatotoxicity may be more likely or more difficult to attribute to one agent.
How serious is the interaction between Mipomersen and Niacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin at baseline and regularly during combined therapy. Stop or reduce therapy if transaminases rise significantly.
What other medicines interact with Niacin?
MediHelp also lists interactions of Niacin with, for example, Alogliptin-metformin, Atorvastatin, Canagliflozin-metformin. The full list is on the Niacin page.
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