Drug interactions
Mipomersen + Paracetamol
Severity: Moderate
Mipomersen and Paracetamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen causes hepatotoxicity with raised transaminases and hepatic fat accumulation, and paracetamol can add to liver injury, especially at high doses or with chronic use. Together they may make liver enzyme changes harder to interpret and increase hepatic risk.
What this interaction means in plain words
Mipomersen and Paracetamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential through separate mechanisms.
What to do
Keep paracetamol at the lowest effective dose and below the maximum daily limit. Monitor liver enzymes as required by the mipomersen monitoring schedule.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paracetamol
- Ethanol + Paracetamol Major
- Busulfan + Paracetamol Moderate
- Carbamazepine + Paracetamol Moderate
- Cholestyramine + Paracetamol Moderate
- Felbamate + Paracetamol Moderate
- Fosphenytoin + Paracetamol Moderate
Frequently asked questions
Can I take Mipomersen with Paracetamol?
MediHelp rates the interaction as moderate. Mipomersen and Paracetamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen causes hepatotoxicity with raised transaminases and hepatic fat accumulation, and paracetamol can add to liver injury, especially at high doses or with chronic use. Together they may make liver enzyme changes harder to interpret and increase hepatic risk.
How serious is the interaction between Mipomersen and Paracetamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep paracetamol at the lowest effective dose and below the maximum daily limit. Monitor liver enzymes as required by the mipomersen monitoring schedule.
What other medicines interact with Paracetamol?
MediHelp also lists interactions of Paracetamol with, for example, Ethanol, Busulfan, Carbamazepine. The full list is on the Paracetamol page.
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