Drug interactions
Mipomersen + Pioglitazone
Severity: Moderate
Mipomersen and Pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise liver enzymes, and mipomersen carries a boxed warning for hepatotoxicity including steatosis. Combined use may increase liver injury risk.
What this interaction means in plain words
Mipomersen and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity potential; no pharmacokinetic interaction is established.
What to do
Monitor ALT, AST and bilirubin regularly, and stop one or both agents if significant elevations or signs of liver injury occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mipomersen and Pioglitazone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pioglitazone
Frequently asked questions
Can I take Mipomersen with Pioglitazone?
MediHelp rates the interaction as moderate. Mipomersen and Pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise liver enzymes, and mipomersen carries a boxed warning for hepatotoxicity including steatosis. Combined use may increase liver injury risk.
How serious is the interaction between Mipomersen and Pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin regularly, and stop one or both agents if significant elevations or signs of liver injury occur.
What other medicines interact with Pioglitazone?
MediHelp also lists interactions of Pioglitazone with, for example, Insulin aspart-insulin aspart protamine, Insulin aspart, Insulin degludec-insulin aspart. The full list is on the Pioglitazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
