Drug interactions
Mipomersen + Tamoxifen
Severity: Moderate
Mipomersen and Tamoxifen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise liver enzymes and cause hepatic fat accumulation, so combined use may increase hepatotoxicity risk. Mipomersen carries a boxed warning for hepatotoxicity.
What this interaction means in plain words
Mipomersen and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity.
What to do
Monitor ALT, AST and bilirubin at baseline and regularly during co-administration, and stop mipomersen if significant elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamoxifen
- Amiodarone + Tamoxifen Major
- Anastrozole + Tamoxifen Major
- Bupropion + Tamoxifen Major
- Carbamazepine + Tamoxifen Major
- Cinacalcet + Tamoxifen Major
- Dacomitinib + Tamoxifen Major
Frequently asked questions
Can I take Mipomersen with Tamoxifen?
MediHelp rates the interaction as moderate. Mipomersen and Tamoxifen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise liver enzymes and cause hepatic fat accumulation, so combined use may increase hepatotoxicity risk. Mipomersen carries a boxed warning for hepatotoxicity.
How serious is the interaction between Mipomersen and Tamoxifen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin at baseline and regularly during co-administration, and stop mipomersen if significant elevations occur.
What other medicines interact with Tamoxifen?
MediHelp also lists interactions of Tamoxifen with, for example, Amiodarone, Anastrozole, Bupropion. The full list is on the Tamoxifen page.
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