Drug interactions
Mipomersen + Tetracycline
Severity: Moderate
Mipomersen and Tetracycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both tetracycline and mipomersen can elevate liver enzymes, and mipomersen carries a boxed warning for hepatotoxicity. Using them together may add to the risk of liver injury, although the combination is not specifically well studied.
What this interaction means in plain words
Mipomersen and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxic potential; no pharmacokinetic mechanism established.
What to do
Monitor ALT, AST and bilirubin during combined use and stop the offending drug if significant transaminase elevation develops. Consider an alternative antibiotic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tetracycline
- Acitretin + Tetracycline Contraindicated
- Methoxyflurane + Tetracycline Contraindicated
- Isotretinoin + Tetracycline Major
- Palovarotene + Tetracycline Major
- Strontium ranelate + Tetracycline Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Mipomersen with Tetracycline?
MediHelp rates the interaction as moderate. Mipomersen and Tetracycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both tetracycline and mipomersen can elevate liver enzymes, and mipomersen carries a boxed warning for hepatotoxicity. Using them together may add to the risk of liver injury, although the combination is not specifically well studied.
How serious is the interaction between Mipomersen and Tetracycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin during combined use and stop the offending drug if significant transaminase elevation develops. Consider an alternative antibiotic if feasible.
What other medicines interact with Tetracycline?
MediHelp also lists interactions of Tetracycline with, for example, Acitretin, Methoxyflurane, Isotretinoin. The full list is on the Tetracycline page.
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