Drug interactions
Mipomersen + Vitamin b3
Severity: Moderate
Mipomersen and Vitamin b3: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen carries a boxed warning for hepatotoxicity, and niacin at lipid-lowering doses can also raise liver enzymes. Using them together may add to the risk of liver injury.
What this interaction means in plain words
Mipomersen and Vitamin b3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity from two agents that can each raise transaminases.
What to do
Monitor liver enzymes and bilirubin at baseline and regularly during combined use. Interrupt therapy if transaminases rise significantly or liver injury is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vitamin b3
- Lovastatin + Vitamin b3 Major
- Simvastatin + Vitamin b3 Major
- Atorvastatin + Vitamin b3 Moderate
- Cholestyramine + Vitamin b3 Moderate
- Colestipol + Vitamin b3 Moderate
- Fluvastatin + Vitamin b3 Moderate
Frequently asked questions
Can I take Mipomersen with Vitamin b3?
MediHelp rates the interaction as moderate. Mipomersen and Vitamin b3 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen carries a boxed warning for hepatotoxicity, and niacin at lipid-lowering doses can also raise liver enzymes. Using them together may add to the risk of liver injury.
How serious is the interaction between Mipomersen and Vitamin b3?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and bilirubin at baseline and regularly during combined use. Interrupt therapy if transaminases rise significantly or liver injury is suspected.
What other medicines interact with Vitamin b3?
MediHelp also lists interactions of Vitamin b3 with, for example, Lovastatin, Simvastatin, Atorvastatin. The full list is on the Vitamin b3 page.
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