Drug interactions
Mitoxantrone + Olaparib
Severity: Major
Mitoxantrone and Olaparib: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause bone marrow suppression, and together they may produce deeper or longer-lasting cytopenias. Rare cases of secondary myelodysplastic syndrome or leukemia are associated with each agent.
What this interaction means in plain words
Mitoxantrone and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mitoxantrone belongs to Central Nervous System; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppression from DNA damage by mitoxantrone and PARP inhibition by olaparib.
What to do
Monitor complete blood counts frequently and reduce doses or delay treatment for significant cytopenias. Avoid the combination outside specialist oncology supervision.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mitoxantrone and Olaparib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Mitoxantrone
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Mitoxantrone with Olaparib?
MediHelp rates the interaction as major. Mitoxantrone and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause bone marrow suppression, and together they may produce deeper or longer-lasting cytopenias. Rare cases of secondary myelodysplastic syndrome or leukemia are associated with each agent.
How serious is the interaction between Mitoxantrone and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce doses or delay treatment for significant cytopenias. Avoid the combination outside specialist oncology supervision.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
