Drug interactions
Mitoxantrone + Phenytoin
Severity: Moderate
Mitoxantrone and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chemotherapy including cytotoxic regimens can lower phenytoin concentrations through reduced absorption or altered metabolism, risking seizure breakthrough. For mitoxantrone specifically the evidence is limited and the mechanism unclear.
What this interaction means in plain words
Mitoxantrone and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitoxantrone belongs to Central Nervous System; Phenytoin belongs to Central Nervous System.
Why it happens
Mechanism not well established; possible reduced absorption or altered clearance of phenytoin.
What to do
Monitor phenytoin serum concentrations and seizure control, adjusting the dose as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Mitoxantrone with Phenytoin?
MediHelp rates the interaction as moderate. Mitoxantrone and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chemotherapy including cytotoxic regimens can lower phenytoin concentrations through reduced absorption or altered metabolism, risking seizure breakthrough. For mitoxantrone specifically the evidence is limited and the mechanism unclear.
How serious is the interaction between Mitoxantrone and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin serum concentrations and seizure control, adjusting the dose as required.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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