Drug interactions
Mitoxantrone + Ponatinib
Severity: Moderate
Mitoxantrone and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits BCRP and P-glycoprotein in vitro, and mitoxantrone is a substrate of BCRP. Exposure to mitoxantrone may increase. Both drugs also carry myelosuppressive and cardiac toxicity.
What this interaction means in plain words
Mitoxantrone and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitoxantrone belongs to Central Nervous System; Ponatinib belongs to Oncology.
Why it happens
Ponatinib may inhibit BCRP/P-gp efflux of mitoxantrone, and both drugs have additive toxicities.
What to do
Monitor blood counts and cardiac function, and reduce mitoxantrone dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mitoxantrone and Ponatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mitoxantrone
Other interactions of Ponatinib
Frequently asked questions
Can I take Mitoxantrone with Ponatinib?
MediHelp rates the interaction as moderate. Mitoxantrone and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits BCRP and P-glycoprotein in vitro, and mitoxantrone is a substrate of BCRP. Exposure to mitoxantrone may increase. Both drugs also carry myelosuppressive and cardiac toxicity.
How serious is the interaction between Mitoxantrone and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function, and reduce mitoxantrone dose if toxicity develops.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
