Drug interactions
Mitoxantrone + Sofosbuvir / velpatasvir
Severity: Moderate
Mitoxantrone and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits BCRP, a transporter that handles mitoxantrone, so mitoxantrone exposure may increase. This could worsen myelosuppression and cardiotoxicity.
What this interaction means in plain words
Mitoxantrone and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Velpatasvir inhibits BCRP-mediated efflux of mitoxantrone.
What to do
Monitor blood counts and cardiac status during coadministration. Consider mitoxantrone dose reduction if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Frequently asked questions
Can I take Mitoxantrone with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Mitoxantrone and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits BCRP, a transporter that handles mitoxantrone, so mitoxantrone exposure may increase. This could worsen myelosuppression and cardiotoxicity.
How serious is the interaction between Mitoxantrone and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac status during coadministration. Consider mitoxantrone dose reduction if toxicity occurs.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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