Drug interactions
Mobocertinib + Nilotinib
Severity: Major
Mobocertinib and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and mobocertinib has a boxed warning for QTc prolongation and torsades de pointes. Combined use increases the arrhythmia risk. Nilotinib may also raise mobocertinib exposure through CYP3A4 inhibition.
What this interaction means in plain words
Mobocertinib and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition by nilotinib raising mobocertinib levels.
What to do
Avoid the combination if possible. If necessary, reduce the mobocertinib dose per labeling and monitor ECG and electrolytes frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Mobocertinib with Nilotinib?
MediHelp rates the interaction as major. Mobocertinib and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and mobocertinib has a boxed warning for QTc prolongation and torsades de pointes. Combined use increases the arrhythmia risk. Nilotinib may also raise mobocertinib exposure through CYP3A4 inhibition.
How serious is the interaction between Mobocertinib and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If necessary, reduce the mobocertinib dose per labeling and monitor ECG and electrolytes frequently.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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