Drug interactions
Mobocertinib + Pimavanserin
Severity: Major
Mobocertinib and Pimavanserin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib carries a boxed warning for QTc prolongation and torsades de pointes, and pimavanserin also prolongs the QT interval. Mobocertinib is also a CYP3A4 substrate and inducer-inhibitor with complex effects, adding uncertainty. The combined effect raises the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Mobocertinib and Pimavanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QTc prolongation.
What to do
Avoid the combination where possible. If unavoidable, monitor ECG and electrolytes frequently and reduce the mobocertinib dose as per labeling when QTc rises.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Mobocertinib with Pimavanserin?
MediHelp rates the interaction as major. Mobocertinib and Pimavanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib carries a boxed warning for QTc prolongation and torsades de pointes, and pimavanserin also prolongs the QT interval. Mobocertinib is also a CYP3A4 substrate and inducer-inhibitor with complex effects, adding uncertainty. The combined effect raises the risk of serious ventricular arrhythmia.
How serious is the interaction between Mobocertinib and Pimavanserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If unavoidable, monitor ECG and electrolytes frequently and reduce the mobocertinib dose as per labeling when QTc rises.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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