Drug interactions
Mobocertinib + Praziquantel
Severity: Moderate
Mobocertinib and Praziquantel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib is a weak to moderate CYP3A4 inducer and can lower praziquantel exposure. Reduced concentrations may lead to treatment failure in parasitic infection.
What this interaction means in plain words
Mobocertinib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by mobocertinib increases the metabolic clearance of praziquantel.
What to do
Monitor for reduced antiparasitic response and consider a higher praziquantel dose or follow-up parasitological testing if the combination cannot be avoided. Choose a non-inducing alternative where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Praziquantel
- Enzalutamide + Praziquantel Contraindicated
- Praziquantel + Rifampin Contraindicated
- Amobarbital + Praziquantel Major
- Apalutamide + Praziquantel Major
- Butabarbital + Praziquantel Major
- Butalbital + Praziquantel Major
Frequently asked questions
Can I take Mobocertinib with Praziquantel?
MediHelp rates the interaction as moderate. Mobocertinib and Praziquantel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mobocertinib is a weak to moderate CYP3A4 inducer and can lower praziquantel exposure. Reduced concentrations may lead to treatment failure in parasitic infection.
How serious is the interaction between Mobocertinib and Praziquantel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antiparasitic response and consider a higher praziquantel dose or follow-up parasitological testing if the combination cannot be avoided. Choose a non-inducing alternative where possible.
What other medicines interact with Praziquantel?
MediHelp also lists interactions of Praziquantel with, for example, Enzalutamide, Rifampin, Amobarbital. The full list is on the Praziquantel page.
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