Drug interactions
Mobocertinib + Quinine
Severity: Major
Mobocertinib and Quinine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib prolongs the QT interval and quinine does as well, raising the risk of torsades de pointes. Mobocertinib also induces CYP3A4 and may lower quinine concentrations.
What this interaction means in plain words
Mobocertinib and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation plus mobocertinib CYP3A4 induction.
What to do
Avoid if possible. If unavoidable, monitor ECG and electrolytes frequently and reduce mobocertinib per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Mobocertinib with Quinine?
MediHelp rates the interaction as major. Mobocertinib and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib prolongs the QT interval and quinine does as well, raising the risk of torsades de pointes. Mobocertinib also induces CYP3A4 and may lower quinine concentrations.
How serious is the interaction between Mobocertinib and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, monitor ECG and electrolytes frequently and reduce mobocertinib per labeling.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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