Drug interactions
Mobocertinib + Sunitinib
Severity: Major
Mobocertinib and Sunitinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib carries a boxed warning for QTc prolongation and torsades de pointes, and sunitinib can also prolong the QT interval. Coadministration raises the risk of serious arrhythmia.
What this interaction means in plain words
Mobocertinib and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid coadministration where possible. If necessary, reduce the mobocertinib dose per labeling and monitor ECG and electrolytes more frequently.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Mobocertinib with Sunitinib?
MediHelp rates the interaction as major. Mobocertinib and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib carries a boxed warning for QTc prolongation and torsades de pointes, and sunitinib can also prolong the QT interval. Coadministration raises the risk of serious arrhythmia.
How serious is the interaction between Mobocertinib and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible. If necessary, reduce the mobocertinib dose per labeling and monitor ECG and electrolytes more frequently.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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