Drug interactions
Moexipril + Parecoxib
Severity: Moderate
Moexipril and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib, a COX-2 selective NSAID, may blunt the blood pressure lowering effect of moexipril and can worsen renal function when combined with an ACE inhibitor, particularly in dehydrated or older patients.
What this interaction means in plain words
Moexipril and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and promotes sodium and fluid retention, opposing ACE inhibitor effects.
What to do
Monitor blood pressure, serum creatinine and potassium, and maintain hydration. Use the shortest possible course of parecoxib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Moexipril with Parecoxib?
MediHelp rates the interaction as moderate. Moexipril and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib, a COX-2 selective NSAID, may blunt the blood pressure lowering effect of moexipril and can worsen renal function when combined with an ACE inhibitor, particularly in dehydrated or older patients.
How serious is the interaction between Moexipril and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and maintain hydration. Use the shortest possible course of parecoxib.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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