Drug interactions
Moexipril + Phenoxybenzamine
Severity: Moderate
Moexipril and Phenoxybenzamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenoxybenzamine causes irreversible alpha-adrenergic blockade and marked vasodilation. Adding an ACE inhibitor can lead to exaggerated hypotension, especially at first dose.
What this interaction means in plain words
Moexipril and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from alpha-adrenergic blockade and ACE inhibition.
What to do
Start at low doses, titrate slowly and monitor blood pressure including standing measurements.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Moexipril with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Moexipril and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine causes irreversible alpha-adrenergic blockade and marked vasodilation. Adding an ACE inhibitor can lead to exaggerated hypotension, especially at first dose.
How serious is the interaction between Moexipril and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start at low doses, titrate slowly and monitor blood pressure including standing measurements.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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