Drug interactions
Moexipril + Prazosin
Severity: Moderate
Moexipril and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and starting an ACE inhibitor in a patient taking an alpha-blocker such as prazosin can cause an exaggerated drop in blood pressure. Symptomatic hypotension, dizziness and syncope are most likely after the first dose or after a dose increase.
What this interaction means in plain words
Moexipril and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Moexipril belongs to Cardiovascular; Prazosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic vasodilatory and blood pressure lowering effects of ACE inhibition and alpha-1 blockade.
What to do
Start the added agent at a low dose, preferably at bedtime, and monitor blood pressure and orthostatic symptoms after initiation and dose changes. Consider reducing the prazosin dose or holding diuretics when starting moexipril.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Moexipril with Prazosin?
MediHelp rates the interaction as moderate. Moexipril and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and starting an ACE inhibitor in a patient taking an alpha-blocker such as prazosin can cause an exaggerated drop in blood pressure. Symptomatic hypotension, dizziness and syncope are most likely after the first dose or after a dose increase.
How serious is the interaction between Moexipril and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start the added agent at a low dose, preferably at bedtime, and monitor blood pressure and orthostatic symptoms after initiation and dose changes. Consider reducing the prazosin dose or holding diuretics when starting moexipril.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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