Drug interactions
Moexipril + Promazine
Severity: Moderate
Moexipril and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine can cause orthostatic hypotension through alpha-adrenergic blockade, which may add to the blood pressure lowering effect of moexipril. The effect is usually modest but can matter in older patients.
What this interaction means in plain words
Moexipril and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension via alpha-1 adrenergic blockade by the phenothiazine plus ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the dose of either drug if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Moexipril with Promazine?
MediHelp rates the interaction as moderate. Moexipril and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine can cause orthostatic hypotension through alpha-adrenergic blockade, which may add to the blood pressure lowering effect of moexipril. The effect is usually modest but can matter in older patients.
How serious is the interaction between Moexipril and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Reduce the dose of either drug if hypotension occurs.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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