Drug interactions
Moexipril + Rifampin
Severity: Minor
Moexipril and Rifampin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin may lower exposure to the active metabolite of moexipril, potentially weakening its blood pressure lowering effect. The clinical effect is expected to be small and is poorly documented.
What this interaction means in plain words
Moexipril and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Rifampin induces metabolic pathways that may alter moexipril activation and clearance, but the mechanism is not firmly established.
What to do
No routine change is needed. Check blood pressure when rifampin is started or stopped and adjust the moexipril dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Moexipril with Rifampin?
MediHelp rates the interaction as minor. Moexipril and Rifampin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifampin may lower exposure to the active metabolite of moexipril, potentially weakening its blood pressure lowering effect. The clinical effect is expected to be small and is poorly documented.
How serious is the interaction between Moexipril and Rifampin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Check blood pressure when rifampin is started or stopped and adjust the moexipril dose if control is lost.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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