Drug interactions
Moexipril + Salsalate
Severity: Moderate
Moexipril and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate, an NSAID, can blunt the blood pressure lowering effect of moexipril. In combination it may also reduce renal function, particularly in older, volume-depleted or renally impaired patients.
What this interaction means in plain words
Moexipril and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAIDs inhibit synthesis of vasodilatory renal prostaglandins, opposing ACE inhibitor effects and reducing renal perfusion.
What to do
Monitor blood pressure and serum creatinine and potassium, ensure adequate hydration, and use the lowest effective salsalate dose for the shortest time; consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Moexipril with Salsalate?
MediHelp rates the interaction as moderate. Moexipril and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate, an NSAID, can blunt the blood pressure lowering effect of moexipril. In combination it may also reduce renal function, particularly in older, volume-depleted or renally impaired patients.
How serious is the interaction between Moexipril and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum creatinine and potassium, ensure adequate hydration, and use the lowest effective salsalate dose for the shortest time; consider paracetamol as an alternative.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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