Drug interactions
Moexipril + Sodium bicarbonate
Severity: Minor
Moexipril and Sodium bicarbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids such as sodium bicarbonate have been reported to reduce the bioavailability of some ACE inhibitors. The sodium load may also modestly oppose blood pressure control.
What this interaction means in plain words
Moexipril and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Moexipril belongs to Cardiovascular; Sodium bicarbonate belongs to Gastrointestinal Tract.
Why it happens
Raised gastric pH may reduce ACE inhibitor absorption, and sodium loading opposes antihypertensive effect; mechanism poorly established for moexipril.
What to do
Separate moexipril from antacids by about 2 hours and monitor blood pressure if bicarbonate is used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Other interactions of Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderate
- Alendronate + Sodium bicarbonate Moderate
- Amantadine + Sodium bicarbonate Moderate
- Carbonyl iron + Sodium bicarbonate Moderate
- Cefditoren + Sodium bicarbonate Moderate
- Cefpodoxime + Sodium bicarbonate Moderate
Frequently asked questions
Can I take Moexipril with Sodium bicarbonate?
MediHelp rates the interaction as minor. Moexipril and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antacids such as sodium bicarbonate have been reported to reduce the bioavailability of some ACE inhibitors. The sodium load may also modestly oppose blood pressure control.
How serious is the interaction between Moexipril and Sodium bicarbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate moexipril from antacids by about 2 hours and monitor blood pressure if bicarbonate is used regularly.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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