Drug interactions
Moexipril + Trifluoperazine
Severity: Minor
Moexipril and Trifluoperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine has alpha-adrenergic blocking activity that can cause orthostatic hypotension. Combined with an ACE inhibitor such as moexipril, blood pressure lowering may be additive, particularly at treatment start or after dose increases.
What this interaction means in plain words
Moexipril and Trifluoperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic hypotensive effects from phenothiazine alpha-blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or changing either drug. Adjust the antihypertensive dose if symptomatic hypotension develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Moexipril with Trifluoperazine?
MediHelp rates the interaction as minor. Moexipril and Trifluoperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trifluoperazine has alpha-adrenergic blocking activity that can cause orthostatic hypotension. Combined with an ACE inhibitor such as moexipril, blood pressure lowering may be additive, particularly at treatment start or after dose increases.
How serious is the interaction between Moexipril and Trifluoperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or changing either drug. Adjust the antihypertensive dose if symptomatic hypotension develops.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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