Drug interactions
Moexipril + Zotepine
Severity: Moderate
Moexipril and Zotepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zotepine has alpha-adrenergic blocking activity that can lower blood pressure and cause orthostatic hypotension. With an ACE inhibitor this can lead to additive hypotension, including exaggerated responses after the first dose.
What this interaction means in plain words
Moexipril and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effect from alpha-1 adrenergic antagonism and ACE inhibition.
What to do
Monitor blood pressure and warn about dizziness when starting or increasing either drug. Consider lower starting doses and slower titration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Moexipril with Zotepine?
MediHelp rates the interaction as moderate. Moexipril and Zotepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zotepine has alpha-adrenergic blocking activity that can lower blood pressure and cause orthostatic hypotension. With an ACE inhibitor this can lead to additive hypotension, including exaggerated responses after the first dose.
How serious is the interaction between Moexipril and Zotepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and warn about dizziness when starting or increasing either drug. Consider lower starting doses and slower titration.
What other medicines interact with Moexipril?
MediHelp also lists interactions of Moexipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Moexipril page.
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