Drug interactions
Morphine + Nefazodone
Severity: Moderate
Morphine and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone has serotonergic activity and inhibits CYP3A4, and combining it with opioids may add serotonergic and sedative effects. Morphine is not CYP3A4-dependent, so the main concern is sedation and rare serotonin toxicity.
What this interaction means in plain words
Morphine and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic and sedative effects; nefazodone CYP3A4 inhibition is not relevant to morphine.
What to do
Monitor for sedation and signs of serotonin toxicity such as tremor, agitation and hyperthermia. Reduce doses if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Morphine with Nefazodone?
MediHelp rates the interaction as moderate. Morphine and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone has serotonergic activity and inhibits CYP3A4, and combining it with opioids may add serotonergic and sedative effects. Morphine is not CYP3A4-dependent, so the main concern is sedation and rare serotonin toxicity.
How serious is the interaction between Morphine and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and signs of serotonin toxicity such as tremor, agitation and hyperthermia. Reduce doses if symptoms occur.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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