Drug interactions
Morphine + Papaveretum
Severity: Major
Morphine and Papaveretum: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum is a mixture of opium alkaloids that consists mainly of morphine, so combining it with morphine duplicates opioid therapy. The risk of respiratory depression, profound sedation and overdose is increased.
What this interaction means in plain words
Morphine and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive mu-opioid receptor agonism because papaveretum contains morphine.
What to do
Avoid combining the two and use a single opioid at a time, adding papaveretum's morphine content into total dose calculations. Monitor respiratory status if overlap is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Morphine with Papaveretum?
MediHelp rates the interaction as major. Morphine and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum is a mixture of opium alkaloids that consists mainly of morphine, so combining it with morphine duplicates opioid therapy. The risk of respiratory depression, profound sedation and overdose is increased.
How serious is the interaction between Morphine and Papaveretum?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two and use a single opioid at a time, adding papaveretum's morphine content into total dose calculations. Monitor respiratory status if overlap is unavoidable.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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