Drug interactions
Morphine + Pimozide
Severity: Moderate
Morphine and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimozide is sedating and combined with morphine increases CNS depression. Pimozide also prolongs the QT interval, which makes adding other CNS-active drugs and electrolyte disturbances more consequential.
What this interaction means in plain words
Morphine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Morphine belongs to Musculoskeletal; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression; pimozide's QT prolongation is independent of morphine.
What to do
Monitor sedation and respiratory status, and check ECG and electrolytes as is usual during pimozide therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Morphine with Pimozide?
MediHelp rates the interaction as moderate. Morphine and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimozide is sedating and combined with morphine increases CNS depression. Pimozide also prolongs the QT interval, which makes adding other CNS-active drugs and electrolyte disturbances more consequential.
How serious is the interaction between Morphine and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and check ECG and electrolytes as is usual during pimozide therapy.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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