Drug interactions
Morphine + Sage
Severity: Minor
Morphine and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some sage preparations may have mild sedative properties, so additive drowsiness with morphine is theoretically possible. Clinical evidence is lacking and the effect is likely minimal.
What this interaction means in plain words
Morphine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression; the mechanism is theoretical and not well established.
What to do
Advise patients to report excessive sedation when using sage supplements with morphine. No routine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Morphine and Sage, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Morphine with Sage?
MediHelp rates the interaction as minor. Morphine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some sage preparations may have mild sedative properties, so additive drowsiness with morphine is theoretically possible. Clinical evidence is lacking and the effect is likely minimal.
How serious is the interaction between Morphine and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report excessive sedation when using sage supplements with morphine. No routine dose adjustment is needed.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
