Drug interactions
Morphine + Scullcap
Severity: Minor
Morphine and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap herbal preparations have reputed sedative properties and may add to the drowsiness caused by morphine. Evidence is limited and largely theoretical.
What this interaction means in plain words
Morphine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive CNS depression from the herb's reputed GABAergic activity.
What to do
Advise patients to avoid combining sedative herbal products with morphine, or monitor for excess drowsiness if used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Morphine with Scullcap?
MediHelp rates the interaction as minor. Morphine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap herbal preparations have reputed sedative properties and may add to the drowsiness caused by morphine. Evidence is limited and largely theoretical.
How serious is the interaction between Morphine and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid combining sedative herbal products with morphine, or monitor for excess drowsiness if used.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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