Drug interactions
Morphine + Selegiline transdermal
Severity: Major
Morphine and Selegiline transdermal: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline patch labeling contraindicates opioids such as meperidine, tramadol and methadone, and advises caution with other opioids because of rare serotonin syndrome or severe reactions. Morphine has weak serotonergic activity so the risk is lower but cannot be excluded.
What this interaction means in plain words
Morphine and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
MAO inhibition may potentiate opioid toxicity through serotonergic or other poorly characterized mechanisms.
What to do
Avoid if possible; if morphine is required, use low doses and monitor for hypotension, hyperthermia, agitation and excessive sedation. Choose a non-serotonergic analgesic where practical.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Morphine with Selegiline transdermal?
MediHelp rates the interaction as major. Morphine and Selegiline transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selegiline patch labeling contraindicates opioids such as meperidine, tramadol and methadone, and advises caution with other opioids because of rare serotonin syndrome or severe reactions. Morphine has weak serotonergic activity so the risk is lower but cannot be excluded.
How serious is the interaction between Morphine and Selegiline transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if morphine is required, use low doses and monitor for hypotension, hyperthermia, agitation and excessive sedation. Choose a non-serotonergic analgesic where practical.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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