Drug interactions
Morphine + Triclofos
Severity: Moderate
Morphine and Triclofos: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclofos is a sedative-hypnotic whose active metabolite is trichloroethanol, and it adds to the sedative and respiratory depressant effects of morphine. Excess drowsiness, slowed breathing and impaired psychomotor function may occur.
What this interaction means in plain words
Morphine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from the opioid and the sedative-hypnotic.
What to do
Start with reduced doses of one or both agents and monitor sedation level and respiratory rate. Avoid in patients with compromised breathing or in the elderly where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Morphine with Triclofos?
MediHelp rates the interaction as moderate. Morphine and Triclofos can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triclofos is a sedative-hypnotic whose active metabolite is trichloroethanol, and it adds to the sedative and respiratory depressant effects of morphine. Excess drowsiness, slowed breathing and impaired psychomotor function may occur.
How serious is the interaction between Morphine and Triclofos?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses of one or both agents and monitor sedation level and respiratory rate. Avoid in patients with compromised breathing or in the elderly where possible.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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