Drug interactions
Morphine + Trifluoperazine
Severity: Moderate
Morphine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine, a phenothiazine antipsychotic, can increase the sedative, hypotensive and respiratory depressant effects of morphine. The combination may cause excessive drowsiness and reduced alertness.
What this interaction means in plain words
Morphine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via opioid receptor agonism and antipsychotic dopamine, histamine and adrenergic blockade.
What to do
Consider lowering the opioid dose when starting the antipsychotic and monitor sedation, blood pressure and respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Morphine with Trifluoperazine?
MediHelp rates the interaction as moderate. Morphine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine, a phenothiazine antipsychotic, can increase the sedative, hypotensive and respiratory depressant effects of morphine. The combination may cause excessive drowsiness and reduced alertness.
How serious is the interaction between Morphine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the opioid dose when starting the antipsychotic and monitor sedation, blood pressure and respiratory status.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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