Drug interactions
Morphine + Yohimbine
Severity: Minor
Morphine and Yohimbine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist with stimulant properties that may partly oppose opioid sedation, but the clinical effect is unpredictable. Yohimbine may also cause anxiety, hypertension and tachycardia, which may complicate pain and opioid management.
What this interaction means in plain words
Morphine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Pharmacodynamic opposition: noradrenergic stimulation by yohimbine versus opioid CNS depression; the clinical effect is not well established.
What to do
Do not rely on yohimbine to reverse opioid sedation; monitor blood pressure, heart rate and analgesic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Frequently asked questions
Can I take Morphine with Yohimbine?
MediHelp rates the interaction as minor. Morphine and Yohimbine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Yohimbine is an alpha-2 antagonist with stimulant properties that may partly oppose opioid sedation, but the clinical effect is unpredictable. Yohimbine may also cause anxiety, hypertension and tachycardia, which may complicate pain and opioid management.
How serious is the interaction between Morphine and Yohimbine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not rely on yohimbine to reverse opioid sedation; monitor blood pressure, heart rate and analgesic response.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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