Drug interactions
Moxisylyte + Trandolapril
Severity: Moderate
Moxisylyte and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxisylyte is an alpha-adrenergic blocker with vasodilating activity. Together with trandolapril it may cause additive hypotension, including an exaggerated response after the first dose.
What this interaction means in plain words
Moxisylyte and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation and hypotension through alpha-blockade combined with ACE inhibition.
What to do
Start with a low dose of moxisylyte and monitor blood pressure and orthostatic symptoms. Advise the patient to sit or lie down if dizzy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Moxisylyte with Trandolapril?
MediHelp rates the interaction as moderate. Moxisylyte and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxisylyte is an alpha-adrenergic blocker with vasodilating activity. Together with trandolapril it may cause additive hypotension, including an exaggerated response after the first dose.
How serious is the interaction between Moxisylyte and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low dose of moxisylyte and monitor blood pressure and orthostatic symptoms. Advise the patient to sit or lie down if dizzy.
What other medicines interact with Trandolapril?
MediHelp also lists interactions of Trandolapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Trandolapril page.
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