Drug interactions
Moxonidine + Oxazepam
Severity: Moderate
Moxonidine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine is a centrally acting antihypertensive that can cause drowsiness, and oxazepam is a sedating benzodiazepine. Taken together they may produce greater sedation, dizziness and psychomotor impairment than either alone.
What this interaction means in plain words
Moxonidine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression through GABA-A potentiation and central alpha2/imidazoline agonism.
What to do
Start with the lowest effective oxazepam dose and monitor for excessive sedation and hypotension. Advise patients to avoid driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Moxonidine and Oxazepam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Frequently asked questions
Can I take Moxonidine with Oxazepam?
MediHelp rates the interaction as moderate. Moxonidine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine is a centrally acting antihypertensive that can cause drowsiness, and oxazepam is a sedating benzodiazepine. Taken together they may produce greater sedation, dizziness and psychomotor impairment than either alone.
How serious is the interaction between Moxonidine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective oxazepam dose and monitor for excessive sedation and hypotension. Advise patients to avoid driving until the response is known.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
