Drug interactions
Muromonab cd3 + Tocilizumab
Severity: Major
Muromonab cd3 and Tocilizumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining tocilizumab with a potent T-cell depleting antibody markedly increases the risk of serious and opportunistic infection. Both also affect cytokine release, which may mask signs of infection.
What this interaction means in plain words
Muromonab cd3 and Tocilizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression from IL-6 receptor blockade and T-cell depletion.
What to do
Avoid combining where possible. If unavoidable, monitor closely for infection, since tocilizumab can suppress fever and CRP.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Muromonab cd3 with Tocilizumab?
MediHelp rates the interaction as major. Muromonab cd3 and Tocilizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining tocilizumab with a potent T-cell depleting antibody markedly increases the risk of serious and opportunistic infection. Both also affect cytokine release, which may mask signs of infection.
How serious is the interaction between Muromonab cd3 and Tocilizumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible. If unavoidable, monitor closely for infection, since tocilizumab can suppress fever and CRP.
What other medicines interact with Tocilizumab?
MediHelp also lists interactions of Tocilizumab with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Tocilizumab page.
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