Drug interactions
Mycophenolate + Pantoprazole
Severity: Moderate
Mycophenolate and Pantoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pantoprazole raises gastric pH and can lower absorption of mycophenolate mofetil, reducing exposure to mycophenolic acid. This may reduce immunosuppression and raise the risk of rejection, although the enteric-coated sodium formulation is less affected.
What this interaction means in plain words
Mycophenolate and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Increased gastric pH impairs dissolution and absorption of mycophenolate mofetil.
What to do
Monitor for signs of reduced immunosuppression and consider mycophenolic acid exposure monitoring. Consider enteric-coated mycophenolate sodium or review the need for the PPI.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Mycophenolate with Pantoprazole?
MediHelp rates the interaction as moderate. Mycophenolate and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pantoprazole raises gastric pH and can lower absorption of mycophenolate mofetil, reducing exposure to mycophenolic acid. This may reduce immunosuppression and raise the risk of rejection, although the enteric-coated sodium formulation is less affected.
How serious is the interaction between Mycophenolate and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of reduced immunosuppression and consider mycophenolic acid exposure monitoring. Consider enteric-coated mycophenolate sodium or review the need for the PPI.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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